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Thursday, April 30, 2026

The Gainesville Ledger

Education

UF researchers develop experimental drug that floods triple-negative breast cancer cells with toxic lipids

University of Florida scientists have developed an experimental compound, DH20931, that targets triple-negative breast cancer by triggering a buildup of toxic fat-like molecules called ceramides, overwhelming cancer cells. The drug works by targeting an enzyme known as CerS2, which ramps up ceramide production and stresses tumors. Tests on human-derived tumors in mice showed low toxicity, though further research would be needed before any human trials could begin.

Sources: UF News

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